IGF1R是呼吸道同胞病毒的入口受体
Cameron D Griffiths1,2, Leanne M Bilawchuk1,2, John E McDonough3
1Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.
Nature
|June 5, 2020
概括
呼吸道同胞病毒 (RSV) 使用核素作为细胞进入的核心受体. 抑制蛋白激酶C zeta (PKCζ) 阻断了核素的流通,减少了RSV的复制和病理.
科学领域:
- 病毒学
- 细胞生物学
- 免疫学
背景情况:
- 肺炎是全球主要的死亡原因,呼吸道同胞病毒 (RSV) 造成严重的健康负担,治疗选择有限.
- 尽管RSV感染了气道上皮细胞,但病毒进入和受体相互作用的确切机制尚不清楚.
- 核素作为RSV和其他病原体的入口共受体,促进细胞入口.
研究的目的:
- 阐明RSV进入宿主细胞的机制.
- 确定特定细胞信号通路和共受体在RSV感染中的作用.
- 通过了解其进入机制,探索RSV的潜在治疗点.
主要方法:
- 通过检查RSV-F糖蛋白与胰岛素样生长因子-1受体之间的相互作用来研究RSV的进入.
- 研究了蛋白质激酶C zeta (PKCζ) 信号在细胞膜中招募核素中的作用.
- 使用呼吸道器官培养和RSV感染的小鼠模型来评估抑制PKC activation的影响.
主要成果:
- 证明RSV-F与胰岛素类生长因子-1受体的结合会触发PKCζ的激活.
- 显示激活的PKCζ信号从核中招募核素到血,在那里它与RSV颗粒结合.
- 抑制PKCζ激活可以防止核素转移到RSV颗粒,并减少体内病毒的复制和病理.
结论:
- RSV的进入涉及一个信号级联,其中受体参与导致细胞表面的病毒粒子的共受体招募.
- 涉及PKCζ和核素的已确定途径代表了病毒进入的新机制.
- 针对这种途径可能导致针对RSV感染的新治疗策略的开发.
更多相关视频
相关概念视频
Common Respiratory Disorders
1.1K
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.1K
Cystic Fibrosis: Pathogenesis
530
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
530
Acute Respiratory Failure-I
531
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
531
Acute Respiratory Failure-II
627
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
627
Transducer Mechanism: G Protein–Coupled Receptors
3.1K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
GPCRs are also called heptahelical,...
3.1K
Rous Sarcoma Virus (RSV) and Cancer
5.7K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.7K


