反会在视觉皮层的神经元中产生第二个受体场
Andreas J Keller1,2, Morgane M Roth3,4, Massimo Scanziani5,6
1Department of Physiology, University of California San Francisco, San Francisco, CA, USA. andreasjakob.keller@ucsf.edu.
Nature
|June 6, 2020
概括
研究人员在小鼠视觉皮层中发现了一个反受体场 (fbRF),补充了经典的前受体场 (ffRF). 这种fbRF使用视觉背景来增强刺激预测和处理.
科学领域:
- 神经科学
- 视觉系统处理
- 感官神经科学
背景情况:
- 感官通路将器官与大脑联系起来,定义了用于刺激的经典受体场 (ffRF).
- 神经元可以被ffRF之外的刺激激发,这表明依赖于上下文的处理,但机制仍然不清楚.
研究的目的:
- 阐明通过经典前受体场 (ffRF) 外的刺激产生神经元激发的机制.
- 描述小鼠视觉皮层中新发现的反受体场 (fbRF).
主要方法:
- 研究了对小鼠主要视觉皮层激发神经元的反投影.
- 刺激 ffRF 和 fbRF 进行反应特征比较.
- 使用麻醉和沉默较高的视觉区域来评估响应调制.
- 检查了反输入和神经元在皮层上的位置的受体场属性.
主要成果:
- 反投射会产生第二个受体场 (fbRF),由 ffRF 外的刺激驱动.
- 与ffRF刺激相比,fbRF刺激会引起较慢,延迟的反应.
- 通过麻醉和沉默较高的视觉区域来减少反应.
- fbRF和ffRF是相互对抗的,特定的抑制神经元群体表现出不同的反应.
结论:
- fbRF补充了ffRF,使神经元能够使用视觉上下文进行预测处理.
- 反投影有助于估计缺失的信息,并检测整个视觉空间的刺激特征差异.
- 在视觉系统中整合上下文信息时, fbRF 机制至关重要.
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