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Updated: Dec 19, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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通过合作性选择性:与半合成天然产品相互作用的优先稳定

Madita Wolter1, Pim de Vink1, João Filipe Neves2,3

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit Eindhoven, P.O. Box 513, Eindhoven 5600 MB, The Netherlands.

Journal of the American Chemical Society
|June 6, 2020
PubMed
概括

合成蛋白与蛋白相互作用 (PPI) 稳定剂尚未得到充分研究. 这项研究引入了一种半合成衍生物DP-005,可选择性地稳定p65/14-3-3复合体,提供一种新的药物发现方法.

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