酶式生物燃料电池用于自动供电,可控制的药物释放
Xinxin Xiao1,2, Kieran Denis McGourty1,3, Edmond Magner1
1Department of Chemical Sciences and Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Journal of the American Chemical Society
|June 9, 2020
概括
这项研究介绍了使用导电聚合物和生物燃料电池的自动供电药物. 这种系统可控制地释放出像伊布洛芬和DAPI这样的药物,
科学领域:
- 生物医学工程
- 材料科学
- 电化学
背景情况:
- 自动供电的药物输送系统对于临床应用至关重要,减少对外部电源的依赖.
- 导电聚合物 (CPs) 为将药物释放功能与发电相结合提供了一个有前途的平台.
- 酵素生物燃料电池 (EBFC) 可以为此类设备提供可持续的内部电源.
研究的目的:
- 开发和展示使用导电聚合物和酶生物燃料电池的自动供电药物输送系统.
- 通过EBFC的电放电触发模型药物化合物的可控释放.
- 评估在现场的药物输送和释放的化合物的细胞吸收.
主要方法:
- 在阴极上集成CP药物层的氧化氧化聚合物中介葡萄糖/O2EBFC的制造.
- 在葡萄糖和氧气的存在下释放EBFC以触发药物释放.
- 纳入和控制释放模型化合物:伊布洛芬 (IBU),光素 (FLU) 和4',6-二胺-2-英醇 (DAPI).
- 在视网膜色素表皮 (RPE) 细胞中使用DAPI进行现场释放和细胞吸收研究.
主要成果:
- 在EBFC释放时,模型药物化合物的快速释放,在开放电路中释放最小.
- 证明IBU,FLU和DAPI的受控和现场释放
- 在细胞培养基中成功释放DAPI,并随后将其纳入RPE细胞.
- 一个响应的,自动驱动的药物释放机制的概念验证.
结论:
- 开发的系统是一个基于导电聚合物和EBFCs的新型自动供电药物输送平台.
- 这项技术可以通过生物燃料电池活动来控制药物释放.
- 这些发现支持该系统在未来的可植入药物输送装置中的潜在应用.
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