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SARS-CoV-2 的逆遗传学揭示了呼吸道中的可变感染梯度

Yixuan J Hou1, Kenichi Okuda2, Caitlin E Edwards1

  • 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Cell
|June 12, 2020
PubMed
概括

鼻子很容易感染导致COVID-19的病毒 - - 严重急性呼吸综合征冠状病毒2 (SARS-CoV-2). 这种易感性可能导致吸血和肺部感染,解释了COVID-19

关键词:
在ACE2中美国冠状病毒传染性克隆鼻子感染中和试验主要细胞报告病毒呼吸道热带症反向遗传学

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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