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研究领域生物科学生态学气候变化的进化影响
调节小鼠的神经元

调节小鼠的神经元

Sinisa Hrvatin ¹, Senmiao Sun ^2,3, Oren F Wilcox ², Hanqi Yao ², Aurora J Lavin-Peter ², Marcelo Cicconet ⁴, Elena G Assad ², Michaela E Palmer ², Sage Aronson ⁵, Alexander S Banks ⁶, Eric C Griffith ², Michael E Greenberg ⁷

Sinisa Hrvatin ¹, Senmiao Sun ^2,3, Oren F Wilcox ²

¹Department of Neurobiology, Harvard Medical School, Boston, MA, USA. sinisa_hrvatin@hms.harvard.edu.
²Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
³Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
⁴Image and Data Analysis Core, Harvard Medical School, Boston, MA, USA.
⁵Neurophotometrics, Ltd., San Diego, CA, USA.
⁶Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
⁷Department of Neurobiology, Harvard Medical School, Boston, MA, USA. michael_greenberg@hms.harvard.edu.

⁰Department of Neurobiology, Harvard Medical School, Boston, MA, USA. sinisa_hrvatin@hms.harvard.edu.

Nature +

|

2020年六月13日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

研究人员发现了特定的下丘脑神经元, 调节了哺乳动物的生存状态. 这些Adcyap1阳性细胞控制了从这种节能低温状态的进入,维持和唤醒.

科学领域

生理学
神经科学
进化生物学

背景情况

内热是哺乳动物和鸟类进化的关键,涉及到恒定的体温调节.
哺乳动物在恶劣条件下使用和冬眠作为生存策略, 显著降低体温.
控制这些低温状态的神经机制尚不清楚.

研究的目的

研究哺乳动物中的进入和维持的神经调节.
确定参与启动和控制麻木发作的特定神经元群.
了解下丘脑电路在适应性低代谢状态中的作用.

主要方法

研究小鼠的麻木,专注于下丘脑的中间和侧面前视区域.
研究了重新激活先前激活的神经元对的启动的影响.
鉴定和分析了Glutamatergic Adcyap1阳性神经元及其在的调节中的作用.

主要成果

介质和侧向下丘脑中的神经活动调节了小鼠进入麻木状态.
即使没有卡路里限制, 也可以激发特定的神经元.
谷氨酸性Adcyap1阳性神经元的活性决定了死时间,而它们的抑制则破坏了死周期.

结论

一个特定的下丘脑Adcyap1阳性神经元群作为小鼠的核心调节器.
这一发现为研究极端低温和低代谢状态的机制和电路提供了基础.
这使得基因操作能够研究这些古老的适应性.

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The cephalic phase is a conditioned or learned response to familiar foods. Our appetite or desire for a particular food modifies the preparatory responses directed by the brain. Individuals may produce more saliva and stomach...

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