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在人性化小鼠和康复期人类中进行的研究产生了SARS-CoV-2抗体尾酒

Johanna Hansen1, Alina Baum1, Kristen E Pascal1

  • 1Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Science (New York, N.Y.)
|June 17, 2020
PubMed
概括

研究人员通过对人性化小鼠和康复期患者进行研究,开发出针对SARS-CoV-2的强效中和抗体. 这些抗体准了尖蛋白,为治疗抗体尾酒提供了有前途的策略,以对抗病毒逃生突变.

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...