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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

3.4K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
3.4K
Protein Glycosylation01:25

Protein Glycosylation

9.0K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
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相关实验视频

Updated: Dec 18, 2025

A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins
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A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins

Published on: May 29, 2016

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单个甘氨酸的成像

X Wu1, M Delbianco2, K Anggara1

  • 1Max Planck Institute for Solid State Research, Stuttgart, Germany.

Nature
|June 20, 2020
PubMed
概括
此摘要是机器生成的。

这是科学家首次直接拍摄单个甘氨酸分子. 这一突破使得可视化甘氨酸的连接性和结构,进步碳水化合物科学.

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Glycan Node Analysis: A Bottom-up Approach to Glycomics
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Glycan Node Analysis: A Bottom-up Approach to Glycomics

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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling

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相关实验视频

Last Updated: Dec 18, 2025

A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins
10:32

A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins

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Glycan Node Analysis: A Bottom-up Approach to Glycomics
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Glycan Node Analysis: A Bottom-up Approach to Glycomics

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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling

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科学领域:

  • 碳水化合物化学和结构生物学
  • 生物物理和纳米科学
  • 葡萄糖和葡萄糖生物学

背景情况:

  • 像蛋白质这样的生物分子的成像对于理解它们的结构和功能至关重要.
  • 目前的糖表征方法依赖于间接信息,限制了详细的结构分析.
  • 甘氨酸的复杂性和灵活性需要单分子成像技术.

研究的目的:

  • 开发一种直接实体空间成像单个糖分子的方法.
  • 实现亚纳米分辨率以可视化甘氨酸连接性和异构性.
  • 克服当前间接糖表征技术的局限性.

主要方法:

  • 使用质量选择性,软着陆电喷射离子束沉积的单个糖分子的分离.
  • 使用低温扫描道显微镜对隔离的甘氨酸进行现实空间成像.
  • 实现分子可视化的纳米分辨率.

主要成果:

  • 单个甘氨酸分子的直接成像成功.
  • 在分子水平上可视化糖连接性.
  • 基于它们的直接图像来区分不同的甘氨酸区域异构体.

结论:

  • 现在可以直接对甘氨酸进行成像,
  • 这种技术为了解碳水化合物的结构和功能提供了重大进步.
  • 开辟了糖化学研究和碳水化合物相关生物过程的新途径.