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Updated: Dec 17, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

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通过近距离激活反应疗法开发共价蛋白药物

Qingke Li1, Qu Chen2, Paul C Klauser3

  • 1Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Hangzhou Research Institute of Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Hangzhou 310018, China.

Cell
|June 25, 2020
PubMed
概括

研究人员开发了一种新的方法,通过将特殊的氨基酸纳入PD-1来制造共价蛋白质药物. 这使得它与PD-L1结合得不可逆转,在具有挑战性的疾病中具有强大的抗瘤作用.

关键词:
遗传密码的扩展其他:苏菲克斯生物反应性氨基酸癌症免疫疗法通过点击同价蛋白药物免疫检查点靠近的反应性疗法靠近的反应性硫化物交换不自然的氨基酸

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