在社区中对大动脉大小,动脉瘤和剖析的家族聚类
Jakob Raunsø1, Rebecca J Song2, Ramachandran S Vasan2,3,4
1Department of Cardiology, Herlev and Gentofte Hospital, Denmark (J.R., B.N.).
Circulation
|June 26, 2020
概括
家庭病史显著增加了主动脉动脉瘤和剖析的风险. 由于主动脉扩张的家族聚合,建议对受影响个体的第一级亲属进行查.
科学领域:
- 心血管医学
- 遗传学
- 公共卫生
背景情况:
- 大动脉动脉瘤破裂和大动脉解剖是高死亡率的危及生命的疾病.
- 通过查及早检测可以及时介入并降低死亡率.
- 作为这些疾病的先驱,大动脉扩张的家族聚合仍然不确定.
研究的目的:
- 调查胸部和腹部大动脉扩张的家族风险.
- 估计患有大动脉动脉瘤和剖析的第一级亲属的发病率.
主要方法:
- 利用弗雷明汉心脏研究队列,根据父母的大动脉大小来评估子女的大动脉大小.
- 采用了丹麦全国的行政登记,以比较一级亲属和对照对象中大动脉动脉瘤和剖析发生率.
主要成果:
- 父母位于大动脉大小的上四分之一的后代大动脉大小的几率增加了约3倍.
- 与对照人群相比,患有大动脉动脉瘤或剖析的第一级亲属的危险比率显著增加 (动脉动脉瘤6. 70,剖析9. 24).
- 经过对高血压和双主动脉等并发症进行调整后,这些风险保持一致.
结论:
- 动脉动脉瘤和剖析的预测指标, 证明了家族聚合.
- 在一级亲属中,大动脉动脉瘤和剖析的发病率与常见的心血管疾病相当.
- 这些发现支持在有病史的家庭中对主动脉动脉瘤和剖析进行系统查.
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