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FLT3停止突变增加FLT3连接体水平和自身免疫性甲状腺疾病的风险

Saedis Saevarsdottir1,2,3,4, Thorunn A Olafsdottir5,6, Erna V Ivarsdottir5,7

  • 1deCODE genetics/Amgen, Reykjavik, Iceland. saedis.saevarsdottir@decode.is.

Nature
|June 26, 2020
PubMed
概括

一项全基因组研究发现了与自身免疫性甲状腺疾病相关的99个序列变异,其中包括一个关键的FLT3变异 (rs76428106-C). 这种变异会影响FLT3蛋白的功能,增加其他自身免疫性疾病和急性髓性白血病的风险.

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