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青春期和成年早期的大动脉脂肪条的黑白差异:博加卢萨心脏研究
D S Freedman1, W P Newman, R E Tracy
1Division of Biostatistics and Clinical Epidemiology, Medical College of Wisconsin, Milwaukee.
Circulation
|April 1, 1988
概括
年轻的黑人个人比白人更容易患上大动脉脂肪链 (FS),而不依赖于传统的风险因素. 这表明种族群体之间早期动脉样硬化病变的进展不同.
科学领域:
- 心血管研究研究心血管研究
- 公共卫生 公共卫生
- 病理学 病理学 病理学
背景情况:
- 成年白人群体显示出更先进的大动脉纤维状斑块.
- 青少年黑人人群体与白人同龄人相比,主动脉脂肪条 (FS) 的患病率更高.
- 早期动脉样硬化病变发展的种族差异需要调查.
研究的目的:
- 检查大动脉脂肪链 (FS) 患病率中种族差异的潜在决定因素.
- 调查临床风险因素和年轻死者FS之间的关系.
- 了解从FS过渡到高级动脉样硬化病变的种族变异.
主要方法:
- 来自博加卢萨心脏研究的44名死者 (年龄在6-27岁) 的分析.
- 评估大动脉表面与FS的参与.
- 评估死前风险因素,包括血清脂质,脂蛋白,血压和肥胖.
主要成果:
- 黑人遗体 (n=11) 显示出明显更多的主动脉FS (37%) 比白人遗体 (n=33;16%,p=.0003).
- 这种种族差异持续不论年龄,性别和测量临床风险因素.
- 即使在调整风险因素后,黑人参与FS的比例也增加了16% (p<.001).
结论:
- 青少年早期大动脉脂肪链 (FS) 患病率的种族差异并不能通过传统的临床风险因素来解释.
- 研究结果表明,黑人和白人的动脉样硬化病变的进展有不同的途径.
- 需要进一步的研究来阐明驱动心血管疾病发展中的这些种族差异的机制.
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