T细胞可以在不同类型的细胞上区分异构性主要基因相容性复合体产物
Nature
|April 28, 1988
概括
T细胞受体识别了与主要基因相容性复合体 (MHC) 分子结合的外来抗原. 全基性MHC分子,可能与自我一起,触发T细胞反应的高频率,表明B细胞特异性产物形成了连接体.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- T细胞受体 (TCR) 与由主要基因相容性复合体 (MHC) 分子呈现的抗原片段相互作用.
- 通过T细胞识别外来抗原加上自我MHC通常是低频率的.
- 此外,T细胞对无外来抗原的异性MHC分子也表现出高频反应.
研究的目的:
- 为了研究T细胞受体在异性MHC相互作用期间识别的配体的性质.
- 为了探索与MHC分子复合的自我形成异构配体的假设.
- 为了确定Vβ17a+T细胞受体的全原性配体的细胞源.
主要方法:
- 对T细胞受体与主要基因相容性复合体 (MHC) 配体相互作用的分析.
- 使用与Vβ17a元素的小鼠T细胞受体.
- 研究IE联结体在不同细胞类型上的表达,包括B细胞,巨细胞和感染过的纤维细胞.
主要成果:
- 在使用Vβ17a元素的小鼠T细胞受体和对IE分子的异性形式的反应性之间观察到一种特定的关联.
- 在B细胞上检测到IE连接体.
- 在I-E+巨细胞或感染I-E基因的纤维细胞上没有检测到IE连接体.
结论:
- 这些发现表明,一种B细胞特异性产物与I-E结合,形成异性联体.
- 这支持了所有活性涉及T细胞识别与非抗原复杂的MHC分子的概念.
- 这项研究提供了由特定的T细胞受体对全原性MHC识别的细胞基础的证据.
相关概念视频
Cell-mediated Immune Responses
Overview
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...


