胰腺癌
Jonathan D Mizrahi1, Rishi Surana1, Juan W Valle2
1Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lancet (London, England)
|June 29, 2020
概括
胰腺癌的生存率很低, 症状也很模糊. 通过CT扫描及时检测以及化学疗法和潜在的向疗法等先进治疗提供了更好的结果.
科学领域:
- 癌症学
- 胃肠病学
背景情况:
- 胰腺癌是癌症死亡的主要原因,
- 危险因素包括家族病史,肥胖,二型糖尿病和吸烟.
- 模糊的症状往往导致晚期诊断,使治疗复杂化.
研究的目的:
- 审查目前的胰腺癌诊断和分期方法.
- 概述胰腺癌不同阶段的治疗策略.
- 突出新兴的治疗方法.
主要方法:
- 高质量的计算机断层扫描 (CT) 与静脉对比是检测和切除能力评估的关键.
- 用精细针吸收的内超声波 (EUS) 作为一个补充的分期和诊断工具.
- 患者分为可切除,边缘切除,局部晚期或转移性疾病指导治疗决策.
主要成果:
- 手术切除仍然是胰腺癌的唯一治疗方案.
- 辅助化疗改善了长期的治疗结果.
- 系统化疗方案如FOLFIRINOX和gemcitabine加NAB-paclitaxel是晚期疾病的标准.
结论:
- 对于BRCA突变患者来说,PARP抑制是有前途的,表明向向治疗的方向迈进.
- 对调节瘤微环境的研究可能会提高免疫疗法的有效性.
- 结合手术,化疗和新疗法的多学科方法对于改善胰腺癌的结果至关重要.
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