相关实验视频
Updated: Aug 16, 2026

12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
通过克隆的小鼠白内素-7-7刺激B细胞原始细胞
A E Namen1, S Lupton, K Hjerrild
1Immunex Corporation, Seattle, Washington 98101.
Nature
|June 9, 1988
概括
研究人员发现了一种新的生长因子,即IL-7,它对刺激淋巴细胞原始细胞的增殖和发育至关重要. 这一发现有助于对免疫系统的理解.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 淋巴细胞系细胞的结合和分化途径仍未完全阐明.
- 了解控制早期淋巴细胞发育的调节机制对于免疫学和医学至关重要.
研究的目的:
- 为了确定参与淋巴原生细胞发育的新生长因子.
- 建立一种生物试验,用于检测刺激淋巴细胞原体增殖的因素.
主要方法:
- 利用长期培养系统开发生物试验.
- 在哺乳动物细胞中用于基因克隆的直接表达.
- 隔离了一个编码新增长因子的互补DNA (cDNA) 克隆.
主要成果:
- 成功建立了一种能够检测新增长因子的生物试验.
- 鉴定并分离了这种生长因子的cDNA克隆.
- 指定了新的造血生长因子为白血素-7 (IL-7).
结论:
- 干白素-7 (IL-7) 是一种关键的生长因子,刺激淋巴细胞前体的增殖.
- 鉴定IL-7为研究淋巴细胞发育提供了一个新的工具.
- 这一发现促进了对早期免疫细胞分化的理解.
相关概念视频
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

