海莫菲勒斯b多糖胺疫苗的保护功效
E D Shapiro1, T V Murphy, E R Wald
1Department of Pediatrics, Yale School of Medicine, New Haven, CT 06510-8064.
JAMA
|September 9, 1988
概括
海莫菲勒斯b多糖类疫苗显示出高的保护效果,防止侵袭性海莫菲勒斯流感b型疾病. 这种疫苗在24个月及以上的儿童中非常有效.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 侵袭性Haemophilus influenzae b型 (Hib) 感染对幼儿构成重大威胁.
- 评估Hib多糖疫苗的实际有效性对于公共卫生战略至关重要.
研究的目的:
- 评估Haemophilus b多糖类疫苗对侵入性Hib疾病的保护效果.
- 为了确定疫苗在不同地理区域的有效性.
主要方法:
- 采用了病例控制研究设计,招募了76名患有侵入性Hib疾病的儿童.
- 根据年龄和居住地选择了匹配的对照组 (每例2人).
- 通过医疗记录确认接种疫苗.
主要成果:
- 总体而言,12%的病例和39%的对照人群接种了Hib多糖类疫苗.
- 该疫苗的整体保护效率达到了88%.
- 康涅狄格州 (91%),达拉斯县 (92%) 和匹兹堡 (81%) 的有效性估计很高.
结论:
- 海莫菲勒斯b多糖疫苗在预防儿童侵入性Hib疾病方面非常有效.
- 在24个月或以上的儿童接种疫苗时,疫苗的有效性很强.
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