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首次接触SARS-CoV-2可以防止 rhesus 再次感染

Wei Deng¹, Linlin Bao¹, Jiangning Liu¹

¹Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.

Science (New York, N.Y.)

|July 4, 2020

概括

在 rhesus 中,原发性 SARS-CoV-2 感染会防止再感染. 这项研究显示,初次暴露后免疫反应和中和抗体增强,表明对随后的病毒挑战有保护作用.

科学领域:

病毒学
免疫学
传染性疾病

背景情况:

由SARS-CoV-2引起的2019年新冠肺炎 (COVID-19) 全球大流行,引发了有关康复个体再感染风险的问题.
了解感染后的免疫力对于公共卫生策略和疫苗开发至关重要.

研究的目的:

在 rhesus 模型中调查 SARS-CoV-2 重感染的可能性.
描述原发性感染和随后的SARS-CoV-2复发后的免疫反应.

主要方法:

一种表现为间歇性肺炎和系统性病毒传播的 rhesus 模型的开发.
在初级感染的早期恢复阶段,重新感染同一个SARS-CoV-2菌株的.
在初级感染和再感染之间对 humoral 和细胞免疫的比较分析.

主要成果:

重新感染SARS-CoV-2的 rhesus 没有检测到病毒传播,临床症状或组织病理变化.
主要感染导致中和抗体标位和免疫反应显著增强.
在动物模型中,该研究表明抗再感染的强大保护.

结论:

主要的SARS-CoV-2感染可以防止 rhesus 再次感染.
包括中和抗体在内的增强的 humoral 和细胞免疫力在这种保护作用中起着关键作用.
这些发现对了解COVID-19免疫力和再感染动态有意义.

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