为COVID-19的发病,疫苗接种和治疗创造一个广泛有用的模型
Jing Sun1, Zhen Zhuang1, Jian Zheng2
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510182, China.
Cell
|July 10, 2020
概括
研究人员通过向人类输送ACE2开发了一种用于COVID-19研究的新老鼠模型. 这种模型可以快速测试针对SARS-CoV-2肺炎的疫苗和抗病毒疗法.
科学领域:
- 病毒学
- 免疫学
- 传染性疾病
背景情况:
- 由SARS-CoV-2引起的COVID-19是一种严重的肺炎,全球死亡率很高.
- 疫苗和治疗方法的快速开发至关重要.
- 小鼠是有价值的研究模型,但它们自然抵抗SARS-CoV-2感染.
研究的目的:
- 为了克服小鼠对SARS-CoV-2的耐药性.
- 建立用于评估COVID-19干预措施的小鼠模型.
- 调查宿主因素在SARS-CoV-2病变发生过程中的作用.
主要方法:
- 使用复制缺陷腺病毒 (Ad5-hACE2) 输送人类ACE2 (血管酶转化酶2).
- 在敏感小鼠中诱导类似SARS-CoV-2的肺炎.
- 评估病毒载量,肺病理和宿主免疫反应 (I型干扰素,T细胞,STAT1).
- 对候选疫苗,康复期血和抗病毒药物 (多种I:C,remdesivir) 的评估.
主要成果:
- 患有Ad5-hACE2敏感性的小鼠患有肺炎,体重减轻,肺部病变以及高病毒复制率.
- 确定I型干扰素,T细胞和STAT1对病毒清除和疾病解决至关重要.
- 该模型有助于快速评估疫苗有效性,康复期血和抗病毒治疗.
结论:
- 一种新的Ad5-hACE2转化小鼠模型有效地复制了COVID-19肺炎的关键特征.
- 这种模型广泛适用于调查SARS-CoV-2的病原性.
- 该模型为快速评估潜在的COVID-19疫苗和治疗方法提供了一个平台.
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