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针对肺癌患者进行个性化治疗的全国肺矩阵试验

Gary Middleton^1,2, Peter Fletcher³, Sanjay Popat⁴

¹Institute of Immunology & Immunotherapy, University of Birmingham, Birmingham, UK. g.middleton@bham.ac.uk.

|July 17, 2020

概括

针对非小细胞肺癌 (NSCLC) 的向治疗在与烟草相关的病例中显示出有限的益处. 国家肺矩阵试验发现药物生物标志物组合很少有效,主要是在接触烟草的患者中.

科学领域:

癌症学
基因组学
临床试验

背景情况:

针对非小细胞肺癌 (NSCLC) 的向治疗主要有利于吸烟者较少发生瘤驱动因素的患者.
开发与烟草有关的分层药物是急需的.
雨试验通过查瘤的各种基因组变化,有效地调查多种基因型匹配的治疗方法.

研究的目的:

报告国家肺部基因试验的结果,
通过下一代测序确定药物生物标记组合的有效性.
在多样化的NSCLC患者群体中评估基因型匹配疗法的临床效用.

主要方法:

使用下一代测序来识别瘤基因型,
对5,467名患者进行了查,其中2,007名患者在分子上符合试验条件.
采用贝叶斯试验设计来整合正在进行和已完成的队列数据.

主要成果:

在19个药物生物标志物队列中,有302名患者接受了基因型匹配治疗.
尽管有临床前的理由,但很少有药物生物标志物组合显示出临床相关的益处.
主要在与烟草烟雾接触较少的NSCLC患者中观察到有效治疗方法.

结论:

目前的综合试验数据表明,许多经过测试的药物生物标志物组合在NSCLC中的临床益处有限.
在本试验中,向治疗的有效性仍然集中在非吸烟者或接触烟草最少的人群中.
需要进一步的研究来确定与烟草相关的NSCLC的有效分层治疗方法.

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