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Updated: Dec 14, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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干细胞多能基因Klf4和Oct4调节复杂的SMC表型变化,在晚期动脉样损伤的发病过程中至关重要

Gabriel F Alencar1,2, Katherine M Owsiany1,2, Santosh Karnewar1

  • 1Robert M. Berne Cardiovascular Research Center (G.F.A., K.M.O, S.K., A.N., C.M.W., S.S., C.A.H., R.H., R.A.B., C.A.M., E.R.Z., G.K.O.), University of Virginia, Charlottesville.

Circulation
|July 18, 2020
PubMed
概括

在晚期动脉样硬化中,光滑肌细胞表现出显著的可塑性,转变为各种有害细胞类型. Klf4 调节这些转变,影响斑块的稳定性,并可能导致化.

关键词:
冠状动脉疾病单个核酸多态平滑肌细胞平滑肌肉的分化平滑肌的原始细胞

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