塔吉托克辛的总合成
Chi He1, Hang Chu1, Thomas P Stratton1
1Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Journal of the American Chemical Society
|July 21, 2020
概括
通过一种新的15步路径来合成复杂的tactitoxin分子. 这种合成证实了天然产品
科学领域:
- 有机化学
- 自然产品合成
背景情况:
- 在天然产品合成中,塔吉托克素 (1) 构成了一个结构复杂且长期存在的挑战.
- 之前的塔泰托克辛结构分配经历了多次修订.
研究的目的:
- 为了实现塔克素的总合成 (1).
- 通过全合成来确认tactitoxin的结构.
- 通过生物测试来确定tactitoxin的绝对配置.
主要方法:
- 从可再生原料开始的15步合成路径的开发.
- 使用不寻常的转换,包括重新排列,循环和基于P (V) 的酸盐安装.
- 合成塔克素的两个反体,以方便绝对配置的确定.
主要成果:
- 成功完成了15个步骤的全合成天毒素 (1).
- 证实了tactitoxin引人入胜的结构.
- 通过对两种反体进行生物测试来确定天然产品的绝对配置.
结论:
- 总合成验证了tactitoxin的结构.
- 开发的合成路径提供了对两种反体的访问,使绝对配置的分配成为可能.
- 这项工作解决了天然产品合成的重大挑战.
更多相关视频
11:44Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
13.0K
10:30Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
Published on: September 2, 2015
10.6K
相关概念视频
Types of Toxins
3.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.0K
Tagging and Fusion Proteins
8.2K
Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
8.2K
Formation of Lipopolysaccharides
356
Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin,...
356
