氨酸不会抑制人类肺细胞感染SARS-CoV-2
Markus Hoffmann1,2, Kirstin Mösbauer3,4, Heike Hofmann-Winkler5
1Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany. mhoffmann@dpz.eu.
Nature
|July 23, 2020
概括
氨酸没有有效治疗COVID-19. 这种抗病毒药物在肺细胞中无效,因为它向肺部没有的病毒激活途径,限制了对SARS-CoV-2感染的使用.
科学领域:
- 病毒学
- 药物的转化
- 细胞生物学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行导致全球死亡率显著.
- 药物再利用是加速治疗新出现的COVID-19等传染病的一种策略.
- 一种抗疟疾药物 - - 洛昆已被研究出其抑制SARS-CoV-2复制的潜力.
研究的目的:
- 调查氨酸在治疗SARS-CoV-2感染中的有效性.
- 确定 TMPRSS2 蛋白酶在 SARS-CoV-2 进入和素敏感性的作用.
- 评估黄素作为COVID-19治疗干预的潜力.
主要方法:
- 使用用于TMPRSS2表达的Vero细胞来研究SARS-CoV-2感染.
- 在表达TMPRSS2的Vero细胞中测试了对SARS-CoV-2的抑制作用.
- 在人类肺细胞系Calu-3中评估了克洛洛昆对SARS-CoV-2的疗效.
主要成果:
- 在Vero细胞中TMPRSS2的工程表达使得SARS-CoV-2感染对素不敏感.
- 氨酸未能在表达TMPRSS2的Calu-3人类肺细胞中阻止SARS-CoV-2感染.
- 这些发现表明,克洛洛的作用机制与肺细胞无关.
结论:
- 素对SARS-CoV-2的抗病毒活性取决于特定的病毒激活途径.
- 这种途径在人类肺细胞中不活跃,限制了洛昆对COVID-19的治疗潜力.
- 氨酸不太可能有效预防或治疗SARS-CoV-2在患者中传播.
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