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对非人类灵长类动物的SARS-CoV-2感染使用基

Pauline Maisonnasse¹, Jérémie Guedj², Vanessa Contreras¹

¹Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France.

|July 23, 2020

概括

基 (HCQ) 在细胞培养中表现出抗病毒活性,但没有显著降低SARS-CoV-2感染的的病毒载量. 这些发现不支持HCQ用于治疗COVID-19.

科学领域:

病毒学
传染性疾病
药理学

背景情况:

2019年新冠病毒病 (COVID-19) 是一种全球性流行病,没有经批准的抗病毒治疗方法.
基 (HCQ) 已被研究为一种潜在的COVID-19治疗药物.
目前关于HCQ治疗COVID-19有效性的证据尚不确定.

研究的目的:

评估氧化 (HCQ) 对SARS-CoV-2的体外和体内抗病毒活性.
评估HCQ单独和与阿齐素 (AZTH) 结合在COVID-19的模型中的疗效.

主要方法:

在Vero E6细胞和人类呼吸道上皮模型中进行HCQ的体外检测.
在感染SARS-CoV-2的身上进行体内研究,比较HCQ治疗 (暴露前和暴露后,单独和AZTH) 与安慰剂.
在各种组织中量化病毒载量.

主要成果:

HCQ在Vero E6细胞中表现出抗病毒活性,但在人类呼吸道上皮模型中没有.
无论是HCQ还是HCQ与阿兹罗米辛的组合,都没有显著降低的病毒载量.
作为暴露前预防措施,HCQ没有提供针对SARS-CoV-2感染的保护.

结论:

该研究不支持使用氧化 (HCQ) 治疗COVID-19.
在模型中,单独使用HCQ和与阿兹素 (AZTH) 结合使用均没有显著的治疗益处.
需要进一步的研究来确定有效的抗病毒治疗方法.

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