六个具有参考质量的基因组揭示了蝙蝠适应的演变
David Jebb1,2,3, Zixia Huang4, Martin Pippel1,3
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Nature
|July 24, 2020
概括
参考质量的基因组显示了蝙蝠的飞行,回声定位和免疫适应. 这些基因组资源揭示了蝙蝠独特特征的演变,
科学领域:
- 基因组学
- 进化生物学
- 分子生物学
背景情况:
- 蝙蝠具有飞行,回声定位,长寿和独特的免疫力等卓越的适应能力.
- 了解这些特征的遗传基础对于进化研究至关重要.
研究的目的:
- 为了生成六种蝙蝠的高质量参考基因组.
- 阐明蝙蝠适应的分子和进化基础.
主要方法:
- 长时间测序和先进的脚手架技术.
- 使用TOGA软件和转录学进行综合基因注释.
- 对基因组区域的基因组分析以确定蝙蝠的进化位置.
- 全基因组选,基因丢失/扩张和微RNA变异.
主要成果:
- 产生了六种蝙蝠的参考质量基因组.
- 解决了蝙蝠的基因组,基本上将它们置于Scrotifera中.
- 在听觉基因上发现了积极的选择,
- 发现了免疫基因选择和抗病毒APOBEC3基因扩展的证据.
- 记录的基因组病毒整合表明历史病毒耐受性.
- 验证了蝙蝠特异性的微RNA变异.
结论:
- 具有参考质量的蝙蝠基因组为研究适应提供了必要的资源.
- 基因组洞察力揭示了蝙蝠免疫力和回声定位背后的分子机制.
- 这些发现刺激了与人类健康和疾病相关的研究.
相关概念视频
Convergent Evolution
31.1K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
31.1K
Evolutionary Relationships through Genome Comparisons
6.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.7K
The Evidence for Evolution
47.2K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
47.2K
Viral Mutations
39.3K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
39.3K
Eukaryotic Evolution
39.8K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
39.8K
Gene Duplication and Divergence
7.6K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
7.6K


