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Updated: Dec 13, 2025

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
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Published on: February 3, 2013

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CTCF编排了远程凝聚力驱动的V(D) J重组扫描

Zhaoqing Ba1,2, Jiangman Lou3,4, Adam Yongxin Ye3,4

  • 1Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. zhaoqing.ba@childrens.harvard.edu.

Nature
|July 28, 2020
PubMed
概括

在V(D) J重组过程中,CTCF结合阻碍了RAG扫描. 删除CTCF使RAG能够访问远端V(D) S段,促进原生B细胞的高效V(D) J重组.

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