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Updated: Dec 13, 2025

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CD3ε的多重信号作用及其在CAR-T细胞治疗中的应用

Wei Wu1, Qiuping Zhou1, Takeya Masubuchi2

  • 1State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Cell
|July 31, 2020
PubMed
概括

在T细胞受体中的CD3ε链作为信号调器,招募抑制性激酶来控制信号传递. 这种特性通过提高持久性和抗瘤活性来增强仿真抗原受体 (CAR) - T细胞疗法.

关键词:
CAR-T治疗方法其他美国T细胞受体美国癌症细胞持久性细胞因子的释放没有.化模式定量质谱学

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