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Updated: Dec 13, 2025

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
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Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

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一个活动导向的地图 电 - 半氨酸相互作用 在原始人类T细胞

Ekaterina V Vinogradova1, Xiaoyu Zhang1, David Remillard1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cell
|July 31, 2020
PubMed
概括

科学家在人体T细胞中绘制了3000多种对电友敏感的囊蛋白. 这些发现揭示了开发化学探针和治疗药物的潜在目标, 以调节免疫反应和疾病.

关键词:
其他国家国际贸易委员会一个T细胞基于活动的蛋白质分析化学蛋白质组学同价值的半氨酸电友人类蛋白质降解

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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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