相关实验视频

Updated: Dec 13, 2025

Obtaining Human Microglia from Adult Human Brain Tissue

Obtaining Human Microglia from Adult Human Brain Tissue

Published on: August 30, 2020

人类胎儿的微细胞在发育早期就具有稳定性免疫感应特性

L Kracht¹, M Borggrewe¹, S Eskandar^1,2

¹Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Science (New York, N.Y.)

|August 1, 2020

概括

人类胎儿的微细胞在怀孕早期就会产生免疫感应特性. 这种成熟过程可能会增加孕期中发育中的中枢神经系统对环境因素的脆弱性.

科学领域:

神经科学
免疫学
发育生物学

背景情况:

微细胞是中枢神经系统 (CNS) 中的重要免疫细胞.
它们在人类胎儿中的发育是很难理解的.
微质在组织发育,维护和中枢神经系统疾病中起作用.

研究的目的:

研究人类胎儿微细胞的发育轨迹.
从9到18个妊娠周 (GWs) 进行微质异质性和成熟的特征.

主要方法:

产生单细胞基因表达特征.
分析了大量的染色体可访问性.
研究了人类胎儿发育的9至18GW.

主要成果:

人类胎儿微细胞在整个发育过程中表现出异质性.
微细胞逐渐成熟,具有与成人微细胞相似的特性.
染色体可访问性增加,与成年微质细胞的转录网络相关.

结论:

在胎儿早期的发育过程中,小质细胞会获得成熟的,具有免疫能力的表型.
这种成熟可能使人类中枢神经系统易受孕早期环境的影响.

更多相关视频

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

相关概念视频

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...