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通过原型病原体准备的SARS-CoV-2 mRNA疫苗设计

Kizzmekia S Corbett1, Darin K Edwards2, Sarah R Leist3

  • 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nature
|August 7, 2020
PubMed
概括

一种新的mRNA疫苗mRNA-1273针对SARS-CoV-2尖端蛋白. 这种疫苗产生强烈的免疫反应,并保护小鼠免受COVID-19感染,而不会造成伤害.

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Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
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