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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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调节TREM2重塑瘤骨髓形状,增强抗PD-1免疫疗法

Martina Molgora1, Ekaterina Esaulova1, William Vermi2

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell
|August 14, 2020
PubMed
概括

向TREM2 (在骨髓细胞2表达的触发受体) 可以增强癌症免疫疗法. 在小鼠中阻断TREM2通过改变骨髓细胞群减少了瘤生长,并改善了对抗PD-1治疗的反应.

关键词:
其他:乳腺癌检查点封锁大肠直肠癌人类巨细胞癌症 癌症一个瘤

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