由Hexameric Resorcinarene囊驱动的动态Imine库的动力和热力学调制
Stefania Gambaro1, Carmen Talotta1, Paolo Della Sala1
1Laboratory of Supramolecular Chemistry, Dipartimento di Chimica e Biologia "A. Zambelli", Università di Salerno, Via Giovanni Paolo II, I-84084 Fisciano, Salerno, Italy.
Journal of the American Chemical Society
|August 14, 2020
概括
一个resorcinarene囊影响动态共价胺库 (DCL),通过独特的掠夺作用改变它们的组成. 这种囊诱导的调制表明对DCL组件的选择性控制.
科学领域:
- 超分子化学
- 动态共价化学
- 主机与客户之间的化学反应
背景情况:
- 动态共价库 (DCL) 是通过可逆共价键形成的适应性分子系统.
- 树脂素囊是能够进行分子识别和封装的自我组装的超分子宿主.
- DCL与超分子宿主之间的相互作用可以导致新的适应性行为.
研究的目的:
- 为了研究一个hexameric resorcinarene囊对动态共价 imine库 (DCL) 的组成的影响.
- 探索由复素囊诱导的DCL中的imine成分的动力和热力学调制.
- 评估复杂2×2DCL调节中的复合素囊的选择性.
主要方法:
- 动态共价 imine 库 (DCL) 的形成和描述.
- 自动组装的六米囊.
- 用于监测DCL组成和评估囊-DCL相互作用的光谱和分析技术.
- 在囊的存在下对胺交换反应的动力学和热力学研究.
主要成果:
- 通过对特定的胺基成分的"掠夺性作用",hexameric复氨酸囊显著调节了DCL的组成.
- 在引入复素囊后,DCL的动力和热力学变化都被观察到.
- 复杂的2 × 2 DCL也表现出适应性行为,囊诱导成分的选择性调节,一个组件的选择性达到66%.
结论:
- 六米氨酸囊作为动态共价胺库的选择性调节器.
- 这种主机-客户互动显示出一种强大的策略来控制DCL的组成和行为.
- 这些发现为设计灵敏和选择性的超分子系统开辟了道路.
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