Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.3K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Grey matter degeneration during multiple sclerosis is linked to activation of neuronal necroptosis by oxidized phosphatidylcholines.

Research square·2026
Same author

Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria.

Nature medicine·2026
Same author

Targeting glucagon signaling in metabolic disorders, functional insights from zebrafish receptor knockouts.

Cellular and molecular life sciences : CMLS·2026
Same author

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.

Nature communications·2026
Same author

Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas.

Nature communications·2026
Same author

Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans.

PloS one·2026

相关实验视频

Updated: Dec 12, 2025

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
12:45

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images

Published on: August 31, 2022

3.4K

道穿的纳米管调节神经血管合.

Luis Alarcon-Martinez1,2, Deborah Villafranca-Baughman3,4, Heberto Quintero3,4

  • 1Department of Neuroscience, University of Montreal, Montreal, Quebec, Canada. lalarcon@um.es.

Nature
|August 14, 2020
PubMed
概括

新发现的互细胞道化纳米管 (IP-TNTs) 连接视网膜膜细胞,使通信和协调血流与神经元活动. 对这些纳米管的损伤会损害神经血管合,而它们的保存会恢复功能.

更多相关视频

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.5K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.2K

相关实验视频

Last Updated: Dec 12, 2025

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
12:45

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images

Published on: August 31, 2022

3.4K
Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.5K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.2K

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 身体生理学 身体生理学

背景情况:

  • 神经血管合使血液流与神经元活动相匹配.
  • 细胞位于毛细血管上的战略位置,调节微循环.
  • 皮质细胞在协调毛细血管网络中的作用以前是未知的.

研究的目的:

  • 调查细胞间连接的存在和功能.
  • 为了确定皮细胞是否同步微血管动力学和神经血管合.
  • 阐明这些连接在小鼠视网膜中的作用.

主要方法:

  • 在小鼠视网膜中使用双光子显微镜识别interpericyte道化纳米管 (IP-TNT).
  • 分析IP-TNT结构,有机细胞运输和 (Ca2+) 波传播.
  • 评估IP-TNT功能对光刺激,切除,缺血和药物干预的反应.

主要成果:

  • 发现IP-TNT连接单独的细胞,形成一个功能网络.
  • 已证明的IP-TNTs促进细胞间Ca2+波和有机体运输.
  • 显示的IP-TNTs对于协调光引起的反应和调节神经血管合至关重要.
  • 发现IP-TNT损伤损害了血流调节,而保存则拯救了功能.

结论:

  • IP-TNTs是视网膜神经血管单元的新型结构和功能组成部分.
  • 这些纳米管通过介导细胞细胞之间的通信,这对于协调的毛细血管网络功能至关重要.
  • 在生理和病理条件下,IP-TNTs在调节神经血管合中起着至关重要的作用.