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Updated: Dec 12, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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治疗抗体对人类CD20的结合机制

Anand Kumar1,2,3, Cyril Planchais4,5, Rémi Fronzes3,6

  • 1Membrane Protein Mechanisms Unit, Institut Pasteur, 75015 Paris, France.

Science (New York, N.Y.)
|August 15, 2020
PubMed
概括

针对CD20的I型和II型治疗单克隆抗体具有不同的结合机制. 类型II的mAbs形成终端复合体,而类型I的mAbs增强补体激活,从而改善B细胞恶性病和自身免疫性疾病的治疗.

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