Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

15.8K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
15.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Simultaneous Functional Ultrasound, Intrinsic Optical Signal and Widefield Calcium Neuroimaging.

bioRxiv : the preprint server for biology·2026
Same author

Macrophage-Targeted Single Walled Carbon Nanotubes Stimulate Phagocytosis via pH-dependent Drug Release.

Nano research·2026
Same author

Particle tracking microrheology of cancer cells in living subjects.

Materials today (Kidlington, England)·2026
Same author

Imaging of <i>Staphylococcus aureus</i> infections and biofilms using a selective covalent probe for the unique serine hydrolase FphE.

bioRxiv : the preprint server for biology·2026
Same author

Imaging of Staphylococcus aureus Infections and Biofilms Using a Selective Covalent Probe for the Unique Serine Hydrolase FphE.

Angewandte Chemie (International ed. in English)·2026
Same author

Mycobacteriophage Functionalized Magnetic Nanocrystal Clusters for Highly Sensitive and Rapid Detection of <i>Mycobacterium tuberculosis</i>.

JACS Au·2025

相关实验视频

Updated: Dec 11, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.1K

在活小鼠中触发的降解聚合物

Lina Cui1,2,3,4, Sandro Vivona5,6,7, Bryan Ronain Smith3

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.

Journal of the American Chemical Society
|August 18, 2020
PubMed
概括

研究人员开发了可激活的小分子,这些分子因减少环境而在体内聚合. 这就产生了伪多糖,用于像分子成像这样的潜在生物医学应用.

更多相关视频

Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

29.2K
Intravital Imaging of Neutrophil Priming Using IL-1&#946; Promoter-driven DsRed Reporter Mice
09:34

Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice

Published on: June 22, 2016

9.9K

相关实验视频

Last Updated: Dec 11, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.1K
Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

29.2K
Intravital Imaging of Neutrophil Priming Using IL-1&#946; Promoter-driven DsRed Reporter Mice
09:34

Intravital Imaging of Neutrophil Priming Using IL-1β Promoter-driven DsRed Reporter Mice

Published on: June 22, 2016

9.9K

科学领域:

  • 生物材料科学
  • 聚合物化学
  • 分子成像

背景情况:

  • 智能生物材料对生理刺激做出反应,使其在组织工程,治疗和分子成像中得到应用.
  • 在体内聚合提供了一个新的方法,用于在生物系统中创建功能性生物材料.

研究的目的:

  • 开发和描述能够在体内减少环境下进行现场聚合的小分子.
  • 研究这些聚合物的双模态光学成像潜力.

主要方法:

  • 采用碳水化合物链接剂和二氨酸凝结反应的小分子支架的设计.
  • 由减少环境的变化引发的现场聚合.
  • 使用双模态光学成像对光和光声学特性进行评估.

主要成果:

  • 在减少环境下成功地在现场聚合设计的小分子支架.
  • 在聚合之前和之后证明探测器的光和光声学特性.
  • 在活小鼠中,在局部和全身注射后确认现场聚合.

结论:

  • 在特定的生理条件下,开发的小分子支架能够在现场聚合,形成伪多糖.
  • 这项技术有望用于先进的分子成像和其他需要响应材料的生物医学应用.