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在骨髓细胞中的C9orf72抑制了STING诱导的炎症

Madelyn E McCauley1,2, Jacqueline Gire O'Rourke1,2, Alberto Yáñez3,4

  • 1Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Nature
|August 21, 2020
PubMed
概括

通过过度激活STING- 干扰素通路,骨髓细胞中的C9orf72会导致ALS/ FTD的炎症. 在C9-ALS/FTD患者中抑制这种途径可能会减少疾病症状.

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