生物标志物提高了二型心肌梗塞的分辨率和预后
Yu Horiuchi1,2, Nicholas Wettersten1, Mitul P Patel1
1University of California, San Diego, La Jolla (Y.H., N.W., M.P.P., S.-X.N., G.M.V., L.B.D., A.M.).
像CT-proET1,MR-proADM和MR-proANP这样的生物标志物可以帮助区分2型心肌梗塞 (T2MI) 和1型心肌梗塞 (T1MI). 这些以及其他因素都能预测所有患者的预后,不论心脏病发作类型如何.
科学领域:
- 心脏病学
- 生物标志物发现
- 心肌梗塞病理生理学
背景情况:
- 预计越来越敏感的素测定将增加2型心肌梗塞 (T2MI) 的发生率.
- 目前对T2MI的诊断,风险分层和治疗策略需要进一步定义.
- 生物标志物评估对于区分T2MI与1型心肌梗塞 (T1MI) 是至关重要的.
研究的目的:
- 使用各种生物标志物来区分T2MI和T1MI.
- 评估T2MI患者生物标志物的预后能力.
- 评估生物标志物对预测死亡率和主要心血管不良事件 (MACE) 的有用性.
主要方法:
- 在CHOPIN研究中对胸痛患者的回顾性分析.
- 两个心脏病专家对T1MI和T2MI进行评估.
- 接收器操作特征 (ROC) 曲线分析,以评估生物标志物的诊断和预后能力 (cTnI,copeptin,MR-proANP,CT-proET1,MR-proADM,prokalcitonin).
主要成果:
- 与T1MI患者相比,T2MI患者的MR- proANP,CT- proET1,MR- proADM和公素的基线水平较高.
- 与cTnI相比,CT- proET1,MR- proADM和MR- proANP对T2MI的诊断准确度更高.
- 将生物标志物与临床变量相结合,产生了最高的诊断准确度 (AUC 0. 917);其他生物标志物,不包括cTnI,预测了180天死亡率和MACE.
结论:
- 反映特定病理生理过程的生物标志物可以帮助区分T2MI和T1MI.
- 所有测量的生物标志物,除了cTnI,都是预后的重要预测因素.
- 这些生物标志物的预后效用独立于心肌梗塞类型 (T1MI与T2MI).
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