一个连接等离子膜和质体的防御途径,并被病原体所采用
Laura Medina-Puche1, Huang Tan2, Vivek Dogra1
1Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China.
Cell
|August 26, 2020
概括
植物病原体通过向质体来抑制酸 (SA) 生物合成来劫持防御途径. 这种病毒策略涉及膜关联和特定的向信号,在宿主-病原体相互作用期间破坏植物免疫力.
科学领域:
- 植物病理学
- 分子植物微生物相互作用
- 植物细胞生物学
背景情况:
- 叶绿体是植物防御信号的组成部分.
- 植物-病原体相互作用涉及复杂的分子交叉声.
- 酸 (SA) 是植物免疫力的关键植物激素.
研究的目的:
- 研究植物病毒如何干扰叶绿体介导的防御反应.
- 确定病原体用来向叶绿体的保存机制.
- 阐明亚细胞局部化在植物病原体共同进化的作用.
主要方法:
- 在植物防御激活过程中分析病毒蛋白的局部化.
- 生物化学测试以评估酸 (SA) 的生物合成.
- 蛋白质向信号的识别 (N-myristoylation,叶绿体过渡).
- 对病原体和植物蛋白向的比较分析.
主要成果:
- 一种病毒蛋白在防御激活时转移到质体中,抑制SA生物合成.
- 来自不同王国的病原体通过膜协会趋同地向叶绿体.
- 双重向信号 (N-myristoylation和叶绿体过渡) 介导病原体的毒性.
- 植物蛋白也使用类似的向机制,其中一些激活SA防御.
结论:
- 植物具有血到质体的防御途径.
- 病原体通过抑制SA反应来利用这种毒性途径.
- 亚细胞向是植物病原体相互作用的关键共同进化战场.
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