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在纳米尺度上对cAMP信号进行光学映射

Andreas Bock1, Paolo Annibale1, Charlotte Konrad1

  • 1Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany; Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany.

Cell
|August 27, 2020
PubMed
概括

细胞信号由循环腺单酸盐 (cAMP) 的缓冲扩散精确控制. 基酶 (PDEs) 产生纳米级的cAMP梯度,调节下游蛋白激酶A (PKA) 的激活.

关键词:
FRET生物传感器与G蛋白结合的受体缓冲扩散细胞信号传输分区周期性的AMP光波动光谱学纳米领域基化酶蛋白质激酶A4

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