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Updated: Dec 10, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

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使用质细胞测量兼容的基于活动的探针对蛋白酶进行多重检测

Marcin Poreba1,2, Katarzyna M Groborz1,2, Wioletta Rut2

  • 1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|September 2, 2020
PubMed
概括

研究人员开发了用于质量细胞计的新型兰坦化物标记探针,以同时监测多个蛋白酶活动. 这克服了传统光探针的局限性,使细胞中的酶活性能够进行并行分析.

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相关概念视频

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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