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转基因小鼠的糖尿病是由于胰腺β细胞中I类基因相容性分子的过度表达导致的

J Allison1, I L Campbell, G Morahan

  • 1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

Nature
|June 9, 1988
PubMed
概括

转基因小鼠在胰腺β细胞中过度表达I类基因相容性基因,患上糖尿病. 这表明这些分子在疾病中扮演着直接的角色,独立于免疫细胞的参与.

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