COVID-19 对神经系统的影响
Costantino Iadecola1, Josef Anrather1, Hooman Kamel1
1Feil Family Brain and Mind Research Institute, Clinical Translational Neuroscience Unit, Weill Cornell Medicine, New York, NY 10021, USA.
Cell
|September 4, 2020
概括
COVID-19 病毒 (SARS-CoV-2) 可以引起严重的神经并发症,包括中风和长期神经系统损伤. 这篇评论探讨了病毒如何影响大脑和潜在的治疗方法.
科学领域:
- 神经学
- 传染性疾病
- 病毒学
背景情况:
- 神经复杂症是COVID-19患者疾病和死亡的主要原因.
- 症状包括头痛,厌氧,困惑和中风.
- 对神经系统的长期影响越来越令人担忧.
研究的目的:
- 批判性地评估SARS-CoV-2的神经特异性.
- 阐明神经病变的机制.
- 审查急性和慢性神经后果,并探索未来的研究和治疗策略.
主要方法:
- 文献审查和批判性评估.
- 对SARS-CoV-2神经和神经病变的现有研究进行分析.
- 综合与神经结果相关的发现.
主要成果:
- SARS-CoV-2 具有神经变的潜力,直接或间接影响神经系统.
- 多种机制导致神经病变,包括炎症和血管损伤.
- 在COVID-19患者中观察到急性和慢性神经缺陷.
结论:
- 了解SARS-CoV-2的神经影响对于患者管理至关重要.
- 需要对神经和神经病变产生进一步的研究.
- 开发针对COVID-19相关神经疾病的向疗法至关重要.
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