环卫大气泡细胞隐藏了免疫系统中的细菌,
Arpan Sharma Neupane1, Michelle Willson1, Andrew Krzysztof Chojnacki2
1Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada.
Cell
|September 5, 2020
概括
肺膜巨细胞 (AMs) 在肺部活跃地爬行,有效地清除吸入的细菌. 破坏这种运动会导致有害的炎症,并增加对二次感染的易感性.
科学领域:
- 免疫学
- 肺部生物学
- 微生物学
背景情况:
- 人们每天都吸入大量的空气,
- 膜巨细胞 (AMs) 的数量远远超过膜,这引发了关于它们的保护作用的问题.
- 没有有效的巨细胞防御的病原体入侵可能导致慢性炎症.
研究的目的:
- 研究膜巨细胞 (AMs) 的体内行为和病原体清除能力.
- 确定AM运动性和化学反应在肺免疫中的作用.
- 探索病毒感染如何影响AM功能和二次细菌感染.
主要方法:
- 对肺气泡实时体内成像技术的开发.
- 观察AM行为,包括细菌的爬行和细胞化.
- 对AM化学反应进行实验操作,并评估由此产生的炎症反应.
- 模拟流感A病毒感染以研究其对AM和二次感染的影响.
主要成果:
- 它们是可移动的,利用Kohn的毛孔来导航气泡.
- AM有效地感知,化疗和吸入的细菌 (例如P. aeruginosa,S. aureus).
- 损伤的AM化学反应会导致中性粒细胞过度增加,导致炎症和损伤.
- 流感A病毒感染通过II型干扰素信号破坏AM爬行,增加二次细菌共感染.
结论:
- 它们是动态的,移动的免疫细胞, 对于对抗细菌病原体的肺部防御至关重要.
- 对于预防不适当的炎症和维持肺部平衡来说,AM运动和化疗是必不可少的.
- 病毒感染可能会损害AM功能,增加对二次细菌感染的易感性.
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