主要预防喘:从风险和保护因素到有针对性的预防策略
Erika von Mutius1, Hermelijn H Smits2
1Department of Pediatrics, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany; Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Neuherberg, Germany; Comprehensive Pneumology Center Munich, German Center for Lung Research, Neuherberg, Germany.
Lancet (London, England)
|September 10, 2020
概括
喘是一种复杂的儿童疾病, 有希望的预防策略包括维生素D,孕妇的鱼油和微生物暴露,目前正在研究新的根除方法.
科学领域:
- 免疫学
- 环境健康
- 儿童医学
背景情况:
- 喘的发病是多因素的,受遗传,环境和早期免疫发育的影响.
- 疾病的发病率因时间和地理位置而异.
- 流行病学研究侧重于预防喘的环境暴露.
研究的目的:
- 审查目前和新兴的喘预防和控制策略.
- 突出基于环境因素和免疫调节的有希望的干预措施.
- 强调对抗全球喘负担的新方法的需要.
主要方法:
- 对环境暴露和喘的流行病学研究的审查.
- 分析成功的喘管理计划和初级预防计划.
- 评估用于预防喘的微生物,代谢和虫化合物的临床前研究.
主要成果:
- 成功的喘干预措施包括禁烟和芬兰喘计划等公共卫生计划.
- 通过对母亲补充维生素D或鱼油,
- 临床前研究表明细菌溶解物,代谢物和虫化合物的潜在治疗益处.
结论:
- 环境中的微生物暴露和传统的农村生活方式与喘保护有关.
- 需要进一步的研究才能将前临床发现转化为临床喘治疗.
- 开发新的策略对于减少喘的社会和个人负担至关重要.
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