((II) 德克萨菲林:一种通过近红外光激活的偏磁光声学对比剂
Yaguang Ren1, Adam C Sedgwick2, Jingqin Chen1,2
1Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology, CAS Key Laboratory of Health Informatics, Chinese Academy of Sciences, Shenzhen 518055, China.
Journal of the American Chemical Society
|September 11, 2020
概括
在光声成像方面研究了金属色胺衍生物. 在体内,MMn显示出优越的信号强度和稳定性,没有观察到毒性,这表明它作为瘤诊断的双模成像剂的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学成像技术 生物医学成像技术
- 纳米技术 纳米技术
背景情况:
- 近红外 (NIR) 吸收性对于光声学 (PA) 对比剂至关重要.
- 金属氨酸衍生物为先进的成像应用提供了潜在的潜力.
- 开发有效和安全的对比剂对于准确的瘤诊断至关重要.
研究的目的:
- 为了探索MMn,MGd和MLu金属甲衍生物的NIR吸收性和光声学成像能力.
- 为了评估这些复合物的光稳定性,信号强度和体内性能.
- 评估MMn作为瘤诊断的对比剂的潜力.
主要方法:
- 合成和表征MMn,MGd和MLu金属甲酸衍生物.
- 在水溶液和细胞培养中测量光声学 (PA) 信号强度 (RAW 264.7).
- 在活体PA成像实验中使用前列腺瘤小鼠模型.
- 通过血素和素 (H&E) 染色和全血细胞计 (CBC) 测试进行毒性评估.
主要成果:
- 这三个复合体都表现出极好的光稳定性.
- MMn在水和细胞环境中显示出最高的PA信号强度.
- 在体内研究表明,MMn允许稳定,3D PA成像瘤,没有可观察到对主要器官的有害毒性.
- H&E染色和CBC结果证实了MMn.的安全概况.
结论:
- MMn是一种高效的光声学对比剂,具有卓越的信号强度和光稳定性.
- MMn在体内表现出极好的稳定性,并且在瘤成像中具有有利的安全性.
- 作为一个独立的PA对比剂或双模态PA/MRI剂,MMn具有增强瘤诊断的前景.
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