在水中聚合的小C3-对称分子中的超分子双螺旋
René P M Lafleur1, Svenja Herziger2,3, Sandra M C Schoenmakers1
1Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, The Netherlands.
Journal of the American Chemical Society
|September 16, 2020
概括
研究人员发现-1,3,5-三胺 (BTAs) 在水中形成双螺旋式超分子纤维,挑战了以前的1D堆叠模型. 聚合物组合允许对这些纳米结构进行螺旋式调整.
科学领域:
- 超分子化学
- 材料科学
- 纳米技术
背景情况:
- 超分子纤维是用于生物医学的关键纳米结构,由自组装的两性分子形成.
- 最近的研究表明螺旋结构在racemic形式,虽然没有完全理解.
- -1,3,5-三胺 (BTA) 是用于高分子聚合物研究的水溶性分子.
研究的目的:
- 研究水溶性BTA的自我组装到超分子聚合物.
- 描述这些聚合物的结构,特别是螺旋结构的形成.
- 通过共聚合物组成探索结构参数的调整性,例如螺旋.
主要方法:
- 基于-1,3,5-三胺基 (BTA) 的高分子 (共聚物) 的合成.
- 低温传导电子显微镜 (cryo-TEM) 用于高分辨率成像.
- 三维体积重建以分析螺旋结构和重复.
主要成果:
- 在水中自组合成双螺旋超分子纤维, 而不是简单的1D堆.
- 观察到螺旋重复的距离在15到30纳米之间.
- 通过调整聚合物中不同BTA单体的比率,可以调整螺旋曲率.
- 建议使用二次螺旋体形成作为疏水屏蔽机制,促进双螺旋体的形成.
结论:
- 超分子BTA聚合物在水中形成热力学稳定的双螺旋结构.
- 这些发现挑战了长期以来关于1D分子堆叠在这种纤维中的观点.
- 详细的结构分析对于理解1D超分子纤维的精确分子排列至关重要.
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