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激活:老年人BCG疫苗接种随机临床试验

Evangelos J Giamarellos-Bourboulis¹, Maria Tsilika¹, Simone Moorlag²

¹4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, 124 62 Athens, Greece.

|September 17, 2020

概括

与安慰剂相比,BCG疫苗在老年人中显著减少了40%的新感染. 这项研究表明,BCG可以安全有效地保护老年人免受感染.

科学领域:

免疫学
疫苗学
老年病学

背景情况:

众所周知,Bacillus Calmette-Guérin (BCG) 疫苗可以保护儿童免受除结核病之外的各种感染.
在老年人群中,BCG疫苗对异种保护的潜在益处在很大程度上尚未探索.

研究的目的:

评估BCG疫苗在老年人预防新感染的有效性和安全性.
评估BCG对老年患者第一次感染的发生率和时间的影响.

主要方法:

一项III期,双盲,随机,安慰剂对照试验 (ACTIVATE) 涉及198名老年患者.
参与者在出院时接受了BCG或安慰剂,并在12个月内对新感染进行监测.

主要成果:

接种BCG疫苗显著增加了第一次感染的中位数时间 (16周与安慰剂11周相比).
与安慰剂组相比,BCG组的新感染发生率降低了40% (25. 0%).
对可能源自病毒的呼吸道感染的保护最为显著 (HR 0.21, p=0.013);没有观察到副作用的显著差异.

结论:

BCG疫苗是安全的,并且在保护老年人免受新感染方面表现出有效性.
需要在更大规模的研究中进行进一步的研究来证实这些发现,特别是在防治COVID-19等呼吸道感染方面.

关键词:

一个BCG 细胞因子年长者表观遗传修饰感染发生率呼吸道感染经过训练的免疫接种疫苗

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