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针对COVID-19的动物模型

César Muñoz-Fontela^1,2, William E Dowling³, Simon G P Funnell⁴

¹Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

|September 23, 2020

概括

动物模型对于开发COVID-19疫苗和治疗方法至关重要. 本摘要回顾了针对SARS-CoV-2潜在治疗的临床前测试的当前发现和信息.

科学领域:

病毒学
免疫学
流行病学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 导致了COVID-19大流行,在2019年底出现.
这种病毒已经蔓延到全球,
缺乏先前存在的人类免疫力需要快速开发医疗对策.

研究的目的:

总结COVID-19动物模型的研究结果.
提供疫苗和治疗候选药物的临床前测试信息.

主要方法:

对SARS-CoV-2动物模型的现有研究和数据的审查.
为临床前评估标准编制信息.

主要成果:

动物模型对于加速疫苗和治疗方法的测试至关重要.
已建立的模型有助于了解SARS-CoV-2的病原和免疫反应.
数据支持使用特定的动物模型来评估疫苗的疗效和治疗潜力.

结论:

动物模型在抗击COVID-19大流行中发挥着至关重要的作用.
在动物模型中进行标准化临床前测试对于新疗法的监管批准至关重要.
为了对抗SARS-CoV-2和未来的病毒威胁,需要对动物模型进行持续的研究和改进.

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