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通过N4BP1的caspase-8裂变整合先天免疫信号

Alexander D Gitlin1,2, Klaus Heger3, Alexander F Schubert4

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. adgitlin@stanford.edu.

Nature
|September 24, 2020
PubMed
概括

NEDD4结合蛋白1 (N4BP1) 抑制了细胞因子的产生,并被卡斯巴酶8禁用. 通过酶-8的分裂整合了炎症信号,解释了与酶-8突变相关的免疫缺陷.

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