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具有危及生命的COVID-19患者的I型IFN免疫的先天性错误

Qian Zhang1, Paul Bastard2,3, Zhiyong Liu1

  • 1St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

Science (New York, N.Y.)
|September 25, 2020
PubMed
概括

托尔类受体3 (TLR3) 和干扰素调节因子7 (IRF7) 免疫的遗传缺陷增加了危及生命的COVID-19肺炎的风险. 这些罕见的功能丧失变体甚至在没有先前感染的情况下也会导致严重的疾病.

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