Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

1.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Whole-genome 3D architectural screen reveals modulators of brain DNA structure.

bioRxiv : the preprint server for biology·2026
Same author

A class of metallohydrolases expands bile salt hydrolase activity in the gut.

bioRxiv : the preprint server for biology·2026
Same author

Chemical Proteomics Reveals Regulation of Bile Salt Hydrolases via Oxidative Post-translational Modifications.

Journal of the American Chemical Society·2026
Same author

Chemical proteomics reveals regulation of bile salt hydrolases via oxidative post-translational modifications.

bioRxiv : the preprint server for biology·2025
Same author

Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases.

bioRxiv : the preprint server for biology·2024
Same author

Bile Salt Hydrolase Activity-Based Probes for Monitoring Gut Microbial Bile Acid Metabolism.

Chembiochem : a European journal of chemical biology·2024

相关实验视频

Updated: Dec 7, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
07:46

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

4.0K

使用可光激活免疫调节器进行Th17细胞分化

Bibudha Parasar, Pamela V Chang

    Journal of the American Chemical Society
    |September 25, 2020
    PubMed
    概括
    此摘要是机器生成的。

    研究人员开发了一种可光激活的免疫调节器 (PIM),以精确控制T助手17 (Th17) 细胞的分化. 这种工具可以按需调节Th17细胞,帮助研究免疫反应和炎症疾病.

    更多相关视频

    Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro
    12:08

    Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro

    Published on: November 15, 2024

    815
    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
    07:12

    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

    Published on: April 16, 2015

    53.8K

    相关实验视频

    Last Updated: Dec 7, 2025

    Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
    07:46

    Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

    Published on: October 25, 2024

    4.0K
    Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro
    12:08

    Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro

    Published on: November 15, 2024

    815
    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
    07:12

    Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

    Published on: April 16, 2015

    53.8K

    科学领域:

    • 免疫学
    • 合成生物学
    • 化学生物学

    背景情况:

    • 帮助T细胞17 (Th17) 对于对抗细胞外病原体至关重要.
    • 对于Th17细胞的调节和可塑性仍有很少的了解.
    • 了解Th17细胞动态对于免疫和疾病研究至关重要.

    研究的目的:

    • 开发一种精确的控制Th17细胞分化的方法.
    • 研究Th17细胞的动态功能和行为.
    • 阐明Th17细胞群的调节和可塑性.

    主要方法:

    • 开发了一种可光激活的免疫调节器 (PIM).
    • 在光化学激活时释放基碳酸受体 (AhR) 配体的潜伏激活剂.
    • 使用紫外线来控制AhR激活和Th17分化.

    主要成果:

    • 对Th17细胞分化进行精确的空间和时间控制.
    • 通过使用PIM系统成功调节Th17细胞诱导.
    • 建立了一个新的化学工具来研究免疫细胞的可塑性.

    结论:

    • 这种方法对Th17细胞的分化提供了前所未有的控制.
    • 这种方法有助于深入研究免疫反应中的Th17细胞动态.
    • 在炎症疾病模型中进一步研究Th17细胞的作用.